P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo.

Overexpression of the MDR1 product, P-glycoprotein (Pgp), has been shown to be one of the mechanisms underlying the development of multidrug resistance (MDR). Recently, one mutant p53 has been shown to stimulate the MDR1 gene promoter in vitro, whereas wild-type p53 repressed this activity. We measu...

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Detalles Bibliográficos
Autores principales: De Angelis, P., Stokke, T., Smedshammer, L., Lothe, R. A., Lehne, G., Chen, Y., Clausen, O. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034003/
https://www.ncbi.nlm.nih.gov/pubmed/7640210

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