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Post-operative levamisole may compromise early healing of experimental intestinal anastomoses.

There exists growing interest in immediate post-operative local adjuvant therapy after resection of intestinal malignancies. It is therefore necessary to assess it potential effect on the healing of intestinal anastomoses. Five groups (n = 20) of rats underwent resection and anastomosis of both ileu...

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Autores principales: de Waard, J. W., Wobbes, T., de Man, B. M., van der Linden, C. J., Hendriks, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034010/
https://www.ncbi.nlm.nih.gov/pubmed/7640232
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author de Waard, J. W.
Wobbes, T.
de Man, B. M.
van der Linden, C. J.
Hendriks, T.
author_facet de Waard, J. W.
Wobbes, T.
de Man, B. M.
van der Linden, C. J.
Hendriks, T.
author_sort de Waard, J. W.
collection PubMed
description There exists growing interest in immediate post-operative local adjuvant therapy after resection of intestinal malignancies. It is therefore necessary to assess it potential effect on the healing of intestinal anastomoses. Five groups (n = 20) of rats underwent resection and anastomosis of both ileum and colon: a control group and four experimental groups receiving intraperitoneal 5-fluorouracil (5-FU), 5-FU plus leucovorin, 5-FU plus levamisole or levamisole alone, on the day of surgery and the next 2 days. Animals were killed 3 or 7 days after operation. Another three groups (n = 6) of animals were used to compare anastomotic collagen synthetic capacity in control rats or rats receiving 5-FU or 5-FU plus levamisole. On the third post-operative day, the average anastomotic bursting pressure in the 5-FU/levamisole group was reduced by 36% as compared with the control group, both in ileum (P = 0.02) and in colon (P = 0.01). Values in the other groups were similar to those in the control group. Anastomotic breaking strength was significantly (P < 0.025) lowered in the ileum from the levamisole group at both days 3 and 7. Anastomotic collagen synthetic capacity was strongly reduced in the 5-FU and 5-FU/levamisole groups. However, there was no significant difference between the control group and the four experimental groups with regard to anastomotic hydroxyproline concentration and content, either 3 or 7 days after operation. Thus, limited use of levamisole, alone or in combination with intraperitoneal 5-FU, may compromise intestinal healing.
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spelling pubmed-20340102009-09-10 Post-operative levamisole may compromise early healing of experimental intestinal anastomoses. de Waard, J. W. Wobbes, T. de Man, B. M. van der Linden, C. J. Hendriks, T. Br J Cancer Research Article There exists growing interest in immediate post-operative local adjuvant therapy after resection of intestinal malignancies. It is therefore necessary to assess it potential effect on the healing of intestinal anastomoses. Five groups (n = 20) of rats underwent resection and anastomosis of both ileum and colon: a control group and four experimental groups receiving intraperitoneal 5-fluorouracil (5-FU), 5-FU plus leucovorin, 5-FU plus levamisole or levamisole alone, on the day of surgery and the next 2 days. Animals were killed 3 or 7 days after operation. Another three groups (n = 6) of animals were used to compare anastomotic collagen synthetic capacity in control rats or rats receiving 5-FU or 5-FU plus levamisole. On the third post-operative day, the average anastomotic bursting pressure in the 5-FU/levamisole group was reduced by 36% as compared with the control group, both in ileum (P = 0.02) and in colon (P = 0.01). Values in the other groups were similar to those in the control group. Anastomotic breaking strength was significantly (P < 0.025) lowered in the ileum from the levamisole group at both days 3 and 7. Anastomotic collagen synthetic capacity was strongly reduced in the 5-FU and 5-FU/levamisole groups. However, there was no significant difference between the control group and the four experimental groups with regard to anastomotic hydroxyproline concentration and content, either 3 or 7 days after operation. Thus, limited use of levamisole, alone or in combination with intraperitoneal 5-FU, may compromise intestinal healing. Nature Publishing Group 1995-08 /pmc/articles/PMC2034010/ /pubmed/7640232 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
de Waard, J. W.
Wobbes, T.
de Man, B. M.
van der Linden, C. J.
Hendriks, T.
Post-operative levamisole may compromise early healing of experimental intestinal anastomoses.
title Post-operative levamisole may compromise early healing of experimental intestinal anastomoses.
title_full Post-operative levamisole may compromise early healing of experimental intestinal anastomoses.
title_fullStr Post-operative levamisole may compromise early healing of experimental intestinal anastomoses.
title_full_unstemmed Post-operative levamisole may compromise early healing of experimental intestinal anastomoses.
title_short Post-operative levamisole may compromise early healing of experimental intestinal anastomoses.
title_sort post-operative levamisole may compromise early healing of experimental intestinal anastomoses.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034010/
https://www.ncbi.nlm.nih.gov/pubmed/7640232
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