Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.

Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) gene methylation was evaluated in neoplastic and perineoplastic breast tissues from 20 patients. In both tissues, ER gene methylation was inversely correlated with protein levels, while EGFR gene methylation was not. A preferential...

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Autores principales: Petrangeli, E., Lubrano, C., Ravenna, L., Vacca, A., Cardillo, M. R., Salvatori, L., Sciarra, F., Frati, L., Gulino, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034049/
https://www.ncbi.nlm.nih.gov/pubmed/7547251
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author Petrangeli, E.
Lubrano, C.
Ravenna, L.
Vacca, A.
Cardillo, M. R.
Salvatori, L.
Sciarra, F.
Frati, L.
Gulino, A.
author_facet Petrangeli, E.
Lubrano, C.
Ravenna, L.
Vacca, A.
Cardillo, M. R.
Salvatori, L.
Sciarra, F.
Frati, L.
Gulino, A.
author_sort Petrangeli, E.
collection PubMed
description Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) gene methylation was evaluated in neoplastic and perineoplastic breast tissues from 20 patients. In both tissues, ER gene methylation was inversely correlated with protein levels, while EGFR gene methylation was not. A preferential ER gene hypomethylation was found in neoplastic tissues, suggesting a significant role in neoplastic transformation.
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spelling pubmed-20340492009-09-10 Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues. Petrangeli, E. Lubrano, C. Ravenna, L. Vacca, A. Cardillo, M. R. Salvatori, L. Sciarra, F. Frati, L. Gulino, A. Br J Cancer Research Article Oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) gene methylation was evaluated in neoplastic and perineoplastic breast tissues from 20 patients. In both tissues, ER gene methylation was inversely correlated with protein levels, while EGFR gene methylation was not. A preferential ER gene hypomethylation was found in neoplastic tissues, suggesting a significant role in neoplastic transformation. Nature Publishing Group 1995-10 /pmc/articles/PMC2034049/ /pubmed/7547251 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Petrangeli, E.
Lubrano, C.
Ravenna, L.
Vacca, A.
Cardillo, M. R.
Salvatori, L.
Sciarra, F.
Frati, L.
Gulino, A.
Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
title Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
title_full Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
title_fullStr Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
title_full_unstemmed Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
title_short Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
title_sort gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034049/
https://www.ncbi.nlm.nih.gov/pubmed/7547251
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