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Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy.
A study was made of the prognostic value of measurements of pretreatment serum marker levels in patients with carcinoma of the uterine cervix undergoing radiotherapy. The markers studied were carcinoma antigen 125 (CA125), squamous cell carcinoma antigen (SCC) and tissue polypeptide antigen (TPA). T...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1995
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034081/ https://www.ncbi.nlm.nih.gov/pubmed/8519673 |
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author | Sproston, A. R. Roberts, S. A. Davidson, S. E. Hunter, R. D. West, C. M. |
author_facet | Sproston, A. R. Roberts, S. A. Davidson, S. E. Hunter, R. D. West, C. M. |
author_sort | Sproston, A. R. |
collection | PubMed |
description | A study was made of the prognostic value of measurements of pretreatment serum marker levels in patients with carcinoma of the uterine cervix undergoing radiotherapy. The markers studied were carcinoma antigen 125 (CA125), squamous cell carcinoma antigen (SCC) and tissue polypeptide antigen (TPA). The levels of all three markers increased with disease stage. In a univariate analysis stratifying patients according to either median values or cut-off levels representing the top of the normal range, pretreatment levels predicted patient survival (follow-up times 1-4 years). In a multivariate analysis, disease stage was the most important prognostic variable and, after allowing for stage, only CA125 was a significant independent predictor of treatment outcome. These data suggest that, in carcinoma of the cervix treated with radiotherapy, pretreatment measurements of CA125, but not SCC and TPA, may have a role to play in defining prognosis. |
format | Text |
id | pubmed-2034081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20340812009-09-10 Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. Sproston, A. R. Roberts, S. A. Davidson, S. E. Hunter, R. D. West, C. M. Br J Cancer Research Article A study was made of the prognostic value of measurements of pretreatment serum marker levels in patients with carcinoma of the uterine cervix undergoing radiotherapy. The markers studied were carcinoma antigen 125 (CA125), squamous cell carcinoma antigen (SCC) and tissue polypeptide antigen (TPA). The levels of all three markers increased with disease stage. In a univariate analysis stratifying patients according to either median values or cut-off levels representing the top of the normal range, pretreatment levels predicted patient survival (follow-up times 1-4 years). In a multivariate analysis, disease stage was the most important prognostic variable and, after allowing for stage, only CA125 was a significant independent predictor of treatment outcome. These data suggest that, in carcinoma of the cervix treated with radiotherapy, pretreatment measurements of CA125, but not SCC and TPA, may have a role to play in defining prognosis. Nature Publishing Group 1995-12 /pmc/articles/PMC2034081/ /pubmed/8519673 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Sproston, A. R. Roberts, S. A. Davidson, S. E. Hunter, R. D. West, C. M. Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. |
title | Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. |
title_full | Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. |
title_fullStr | Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. |
title_full_unstemmed | Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. |
title_short | Serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. |
title_sort | serum tumour markers in carcinoma of the uterine cervix and outcome following radiotherapy. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034081/ https://www.ncbi.nlm.nih.gov/pubmed/8519673 |
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