Cytotoxic effect of RB 6145 in human tumour cell lines: dependence on hypoxia, extra- and intracellular pH and drug uptake.

Low pH and hypoxia are a common feature of many solid tumours. This study examined the effect of these two conditions on the cytotoxic properties of the bifunctional agent RB 6145, the prodrug of RSU 1069. The effect of acidic pH on RB 6145 toxicity was examined in six human tumour cell lines under...

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Detalles Bibliográficos
Autores principales: Skarsgard, L. D., Acheson, D. K., Vinczan, A., Wouters, B. G., Heinrichs, B. E., Loblaw, D. A., Minchinton, A. I., Chaplin, D. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034082/
https://www.ncbi.nlm.nih.gov/pubmed/8519663

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