Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).

Resistance to FCE 24517 is not related to the emergence of any of the most frequently observed phenotypes. We have found that two resistant cell lines (L1210/24517 murine leukaemia and LoVo/24517 human colon adenocarcinoma) present congenital modifications in tyrosyl phosphatase and kinase activitie...

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Autores principales: Ciomei, M., Pastori, W., Capolongo, L., Geroni, C., Melegaro, G., Pennella, G., Grandi, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034097/
https://www.ncbi.nlm.nih.gov/pubmed/8519667
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author Ciomei, M.
Pastori, W.
Capolongo, L.
Geroni, C.
Melegaro, G.
Pennella, G.
Grandi, M.
author_facet Ciomei, M.
Pastori, W.
Capolongo, L.
Geroni, C.
Melegaro, G.
Pennella, G.
Grandi, M.
author_sort Ciomei, M.
collection PubMed
description Resistance to FCE 24517 is not related to the emergence of any of the most frequently observed phenotypes. We have found that two resistant cell lines (L1210/24517 murine leukaemia and LoVo/24517 human colon adenocarcinoma) present congenital modifications in tyrosyl phosphatase and kinase activities. Moreover, the cytotoxic activity of FCE 24517 is increased in combination with a tyrosine phosphatase inhibitor and decreased in combination with protein kinase inhibitors, this being in agreement with the hypothesis that the activity of this drug is strictly dependent on the presence of tyrosine phosphorylated protein(s). IMAGES:
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spelling pubmed-20340972009-09-10 Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine). Ciomei, M. Pastori, W. Capolongo, L. Geroni, C. Melegaro, G. Pennella, G. Grandi, M. Br J Cancer Research Article Resistance to FCE 24517 is not related to the emergence of any of the most frequently observed phenotypes. We have found that two resistant cell lines (L1210/24517 murine leukaemia and LoVo/24517 human colon adenocarcinoma) present congenital modifications in tyrosyl phosphatase and kinase activities. Moreover, the cytotoxic activity of FCE 24517 is increased in combination with a tyrosine phosphatase inhibitor and decreased in combination with protein kinase inhibitors, this being in agreement with the hypothesis that the activity of this drug is strictly dependent on the presence of tyrosine phosphorylated protein(s). IMAGES: Nature Publishing Group 1995-12 /pmc/articles/PMC2034097/ /pubmed/8519667 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ciomei, M.
Pastori, W.
Capolongo, L.
Geroni, C.
Melegaro, G.
Pennella, G.
Grandi, M.
Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).
title Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).
title_full Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).
title_fullStr Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).
title_full_unstemmed Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).
title_short Decreased tyrosine phosphorylation in tumour cells resistant to FCE 24517 (tallimustine).
title_sort decreased tyrosine phosphorylation in tumour cells resistant to fce 24517 (tallimustine).
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034097/
https://www.ncbi.nlm.nih.gov/pubmed/8519667
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