Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.

The present study characterised p53 mutations in 44 hepatocellular carcinomas (HCCs) from Chinese patients residing in a high-incidence area. Twelve point mutations (27%) were detected in tumour tissues using single-strand conformation polymorphism analysis followed by direct DNA sequencing. Remarka...

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Autores principales: Shi, C. Y., Phang, T. W., Lin, Y., Wee, A., Li, B., Lee, H. P., Ong, C. N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034128/
https://www.ncbi.nlm.nih.gov/pubmed/7599044
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author Shi, C. Y.
Phang, T. W.
Lin, Y.
Wee, A.
Li, B.
Lee, H. P.
Ong, C. N.
author_facet Shi, C. Y.
Phang, T. W.
Lin, Y.
Wee, A.
Li, B.
Lee, H. P.
Ong, C. N.
author_sort Shi, C. Y.
collection PubMed
description The present study characterised p53 mutations in 44 hepatocellular carcinomas (HCCs) from Chinese patients residing in a high-incidence area. Twelve point mutations (27%) were detected in tumour tissues using single-strand conformation polymorphism analysis followed by direct DNA sequencing. Remarkably, no mutations were observed at codon 249. This is in contrast to HCCs from other high HCC incidence areas with endemic aflatoxin exposures, in which codon 249 is a mutational hot spot. It is therefore suggested that risk factors other than dietary exposure to aflatoxin may contribute to the high HCC incidence in Singapore. IMAGES:
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spelling pubmed-20341282009-09-10 Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore. Shi, C. Y. Phang, T. W. Lin, Y. Wee, A. Li, B. Lee, H. P. Ong, C. N. Br J Cancer Research Article The present study characterised p53 mutations in 44 hepatocellular carcinomas (HCCs) from Chinese patients residing in a high-incidence area. Twelve point mutations (27%) were detected in tumour tissues using single-strand conformation polymorphism analysis followed by direct DNA sequencing. Remarkably, no mutations were observed at codon 249. This is in contrast to HCCs from other high HCC incidence areas with endemic aflatoxin exposures, in which codon 249 is a mutational hot spot. It is therefore suggested that risk factors other than dietary exposure to aflatoxin may contribute to the high HCC incidence in Singapore. IMAGES: Nature Publishing Group 1995-07 /pmc/articles/PMC2034128/ /pubmed/7599044 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shi, C. Y.
Phang, T. W.
Lin, Y.
Wee, A.
Li, B.
Lee, H. P.
Ong, C. N.
Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
title Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
title_full Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
title_fullStr Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
title_full_unstemmed Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
title_short Codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic Chinese in Singapore.
title_sort codon 249 mutation of the p53 gene is a rare event in hepatocellular carcinomas from ethnic chinese in singapore.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034128/
https://www.ncbi.nlm.nih.gov/pubmed/7599044
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