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Improved silencing properties using small internally segmented interfering RNAs

RNA interference is mediated by small interfering RNAs (siRNAs) that upon incorporation into the RNA-induced silencing complex (RISC) can target complementary mRNA for degradation. Standard siRNA design usually feature a 19–27 base pair contiguous double-stranded region that is believed to be import...

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Detalles Bibliográficos
Autores principales:	Bramsen, Jesper B., Laursen, Maria B., Damgaard, Christian K., Lena, Suzy W., Ravindra Babu, B., Wengel, Jesper, Kjems, Jørgen
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034465/ https://www.ncbi.nlm.nih.gov/pubmed/17726057 http://dx.doi.org/10.1093/nar/gkm548

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