Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization

Human ERCC1/XPF is a structure-specific endonuclease involved in multiple DNA repair pathways. We present the solution structure of the non-catalytic ERCC1 central domain. Although this domain shows structural homology with the catalytically active XPF nuclease domain, functional investigation revea...

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Detalles Bibliográficos
Autores principales: Tripsianes, Konstantinos, Folkers, Gert E., Zheng, Chao, Das, Devashish, Grinstead, Jeffrey S., Kaptein, Robert, Boelens, Rolf
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034474/
https://www.ncbi.nlm.nih.gov/pubmed/17720715
http://dx.doi.org/10.1093/nar/gkm503

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