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Novel high-resolution characterization of ancient DNA reveals C > U-type base modification events as the sole cause of post mortem miscoding lesions

Ancient DNA (aDNA) research has long depended on the power of PCR to amplify trace amounts of surviving genetic material from preserved specimens. While PCR permits specific loci to be targeted and amplified, in many ways it can be intrinsically unsuited to damaged and degraded aDNA templates. PCR a...

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Detalles Bibliográficos
Autores principales:	Brotherton, Paul, Endicott, Phillip, Sanchez, Juan J., Beaumont, Mark, Barnett, Ross, Austin, Jeremy, Cooper, Alan
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034480/ https://www.ncbi.nlm.nih.gov/pubmed/17715147 http://dx.doi.org/10.1093/nar/gkm588

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