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Therapeutic Effect of a Poly(ADP-Ribose) Polymerase-1 Inhibitor on Experimental Arthritis by Downregulating Inflammation and Th1 Response

Poly(ADP-ribose) polymerase-1 (PARP-1) synthesizes and transfers ADP ribose polymers to target proteins, and regulates DNA repair and genomic integrity maintenance. PARP-1 also plays a crucial role in the progression of the inflammatory response, and its inhibition confers protection in several mode...

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Detalles Bibliográficos
Autores principales:	Gonzalez-Rey, Elena, Martínez-Romero, Ruben, O'Valle, Francisco, Aguilar-Quesada, Rocío, Conde, Carmen, Delgado, Mario, Oliver, F. Javier
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034533/ https://www.ncbi.nlm.nih.gov/pubmed/17971849 http://dx.doi.org/10.1371/journal.pone.0001071

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