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Metabolic Syndrome features and risk of neural tube defects

BACKGROUND: Maternal obesity and pre-pregnancy diabetes mellitus, features of the metabolic syndrome (MetSyn), are individual risk factors for neural tube defects (NTD). Whether they, in combination with additional features of MetSyn, alter this risk is not known. We evaluated the risk of NTD in ass...

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Autores principales: Ray, Joel G, Thompson, Miles D, Vermeulen, Marian J, Meier, Chris, Wyatt, Philip R, Wong, Pui-Yuen, Summers, Anne M, Farrell, Sandra A, Cole, David EC
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039731/
https://www.ncbi.nlm.nih.gov/pubmed/17880716
http://dx.doi.org/10.1186/1471-2393-7-21
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author Ray, Joel G
Thompson, Miles D
Vermeulen, Marian J
Meier, Chris
Wyatt, Philip R
Wong, Pui-Yuen
Summers, Anne M
Farrell, Sandra A
Cole, David EC
author_facet Ray, Joel G
Thompson, Miles D
Vermeulen, Marian J
Meier, Chris
Wyatt, Philip R
Wong, Pui-Yuen
Summers, Anne M
Farrell, Sandra A
Cole, David EC
author_sort Ray, Joel G
collection PubMed
description BACKGROUND: Maternal obesity and pre-pregnancy diabetes mellitus, features of the metabolic syndrome (MetSyn), are individual risk factors for neural tube defects (NTD). Whether they, in combination with additional features of MetSyn, alter this risk is not known. We evaluated the risk of NTD in association with maternal features of the MetSyn. METHODS: We used a population-based case-control study design in the province of Ontario, Canada. Cases and controls were derived from women who underwent antenatal maternal screening (MSS) at 15 to 20 weeks' gestation. There were 89 maternal cases with, and 434 controls without, an NTD-affected singleton pregnancy. Maternal features of MetSyn were defined by the presence of pre-pregnancy diabetes mellitus, body weight ≥ 90th centile among controls, non-white ethnicity and/or serum highly sensitive C-reactive protein (hsCRP) ≥ 75th centile of controls. Since hsCRP naturally increases in pregnancy, analyses were performed with, and without, the inclusion of hsCRP in the model. RESULTS: Mean hsCRP concentrations were exceptionally high among study cases and controls (6.1 and 6.4 mg/L, respectively). When hsCRP was excluded from the model, the adjusted odds ratios for NTD were 1.9 (95% confidence interval 1.1–3.4) in the presence 1 feature of MetSyn, and 6.1 (1.1–32.9) in the presence of 2 or more features. When hsCRP was included, the respective risk estimates were attenuated to 1.6 (0.88–2.8) and 3.1 (1.2–8.3). CONCLUSION: We found about 2-fold and 6-fold higher risk for NTD in the presence 1, and 2 or more features, of the metabolic syndrome, respectively. It is not clear whether this risk is altered by the presence of a high serum hsCRP concentration.
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spelling pubmed-20397312007-10-20 Metabolic Syndrome features and risk of neural tube defects Ray, Joel G Thompson, Miles D Vermeulen, Marian J Meier, Chris Wyatt, Philip R Wong, Pui-Yuen Summers, Anne M Farrell, Sandra A Cole, David EC BMC Pregnancy Childbirth Research Article BACKGROUND: Maternal obesity and pre-pregnancy diabetes mellitus, features of the metabolic syndrome (MetSyn), are individual risk factors for neural tube defects (NTD). Whether they, in combination with additional features of MetSyn, alter this risk is not known. We evaluated the risk of NTD in association with maternal features of the MetSyn. METHODS: We used a population-based case-control study design in the province of Ontario, Canada. Cases and controls were derived from women who underwent antenatal maternal screening (MSS) at 15 to 20 weeks' gestation. There were 89 maternal cases with, and 434 controls without, an NTD-affected singleton pregnancy. Maternal features of MetSyn were defined by the presence of pre-pregnancy diabetes mellitus, body weight ≥ 90th centile among controls, non-white ethnicity and/or serum highly sensitive C-reactive protein (hsCRP) ≥ 75th centile of controls. Since hsCRP naturally increases in pregnancy, analyses were performed with, and without, the inclusion of hsCRP in the model. RESULTS: Mean hsCRP concentrations were exceptionally high among study cases and controls (6.1 and 6.4 mg/L, respectively). When hsCRP was excluded from the model, the adjusted odds ratios for NTD were 1.9 (95% confidence interval 1.1–3.4) in the presence 1 feature of MetSyn, and 6.1 (1.1–32.9) in the presence of 2 or more features. When hsCRP was included, the respective risk estimates were attenuated to 1.6 (0.88–2.8) and 3.1 (1.2–8.3). CONCLUSION: We found about 2-fold and 6-fold higher risk for NTD in the presence 1, and 2 or more features, of the metabolic syndrome, respectively. It is not clear whether this risk is altered by the presence of a high serum hsCRP concentration. BioMed Central 2007-09-19 /pmc/articles/PMC2039731/ /pubmed/17880716 http://dx.doi.org/10.1186/1471-2393-7-21 Text en Copyright © 2007 Ray et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ray, Joel G
Thompson, Miles D
Vermeulen, Marian J
Meier, Chris
Wyatt, Philip R
Wong, Pui-Yuen
Summers, Anne M
Farrell, Sandra A
Cole, David EC
Metabolic Syndrome features and risk of neural tube defects
title Metabolic Syndrome features and risk of neural tube defects
title_full Metabolic Syndrome features and risk of neural tube defects
title_fullStr Metabolic Syndrome features and risk of neural tube defects
title_full_unstemmed Metabolic Syndrome features and risk of neural tube defects
title_short Metabolic Syndrome features and risk of neural tube defects
title_sort metabolic syndrome features and risk of neural tube defects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039731/
https://www.ncbi.nlm.nih.gov/pubmed/17880716
http://dx.doi.org/10.1186/1471-2393-7-21
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