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Evaluation of limited sampling strategies for tacrolimus

OBJECTIVE: In literature, a great diversity of limited sampling strategies (LSS) have been recommended for tacrolimus monitoring, however proper validation of these strategies to accurately predict the area under the time concentration curve (AUC(0–12)) is limited. The aim of this study was to deter...

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Autores principales: Op den Buijsch, Robert A. M., van de Plas, Afke, Stolk, Leo M. L., Christiaans, Maarten H. L., van Hooff, Johannes P., Undre, Nas A., van Dieijen-Visser, Marja P., Bekers, Otto
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039832/
https://www.ncbi.nlm.nih.gov/pubmed/17712551
http://dx.doi.org/10.1007/s00228-007-0354-9
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author Op den Buijsch, Robert A. M.
van de Plas, Afke
Stolk, Leo M. L.
Christiaans, Maarten H. L.
van Hooff, Johannes P.
Undre, Nas A.
van Dieijen-Visser, Marja P.
Bekers, Otto
author_facet Op den Buijsch, Robert A. M.
van de Plas, Afke
Stolk, Leo M. L.
Christiaans, Maarten H. L.
van Hooff, Johannes P.
Undre, Nas A.
van Dieijen-Visser, Marja P.
Bekers, Otto
author_sort Op den Buijsch, Robert A. M.
collection PubMed
description OBJECTIVE: In literature, a great diversity of limited sampling strategies (LSS) have been recommended for tacrolimus monitoring, however proper validation of these strategies to accurately predict the area under the time concentration curve (AUC(0–12)) is limited. The aim of this study was to determine whether these LSS might be useful for AUC prediction of other patient populations. METHODS: The LSS from literature studied were based on regression equations or on Bayesian fitting using MWPHARM 3.50 (Mediware, Groningen, the Netherlands). The performance was evaluated on 24 of these LSS in our population of 37 renal transplant patients with known AUCs. The results were also compared with the predictability of the regression equation based on the trough concentrations C(0) and C(12) of these 37 patients. Criterion was an absolute prediction error (APE) that differed less than 15% from the complete AUC(0–12) calculated by the trapezoidal rule. RESULTS: Thirteen of the 18 (72%) LSS based on regression analysis were capable of predicting at least 90% of the 37 individual AUC(0–12) within an APE of 15%. Additionally, all but three LSS examined gave a better prediction of the complete AUC(0–12) in comparison with the trough concentrations C(0) or C(12) (mean 62%). All six LSS based on Bayesian fitting predicted <90% of the 37 complete AUC(0–12) correctly (mean 67%). CONCLUSIONS: The present study indicated that implementation of LSS based on regression analysis could produce satisfactory predictions although careful evaluation is necessary.
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spelling pubmed-20398322007-10-29 Evaluation of limited sampling strategies for tacrolimus Op den Buijsch, Robert A. M. van de Plas, Afke Stolk, Leo M. L. Christiaans, Maarten H. L. van Hooff, Johannes P. Undre, Nas A. van Dieijen-Visser, Marja P. Bekers, Otto Eur J Clin Pharmacol Pharmacokinetics and Disposition OBJECTIVE: In literature, a great diversity of limited sampling strategies (LSS) have been recommended for tacrolimus monitoring, however proper validation of these strategies to accurately predict the area under the time concentration curve (AUC(0–12)) is limited. The aim of this study was to determine whether these LSS might be useful for AUC prediction of other patient populations. METHODS: The LSS from literature studied were based on regression equations or on Bayesian fitting using MWPHARM 3.50 (Mediware, Groningen, the Netherlands). The performance was evaluated on 24 of these LSS in our population of 37 renal transplant patients with known AUCs. The results were also compared with the predictability of the regression equation based on the trough concentrations C(0) and C(12) of these 37 patients. Criterion was an absolute prediction error (APE) that differed less than 15% from the complete AUC(0–12) calculated by the trapezoidal rule. RESULTS: Thirteen of the 18 (72%) LSS based on regression analysis were capable of predicting at least 90% of the 37 individual AUC(0–12) within an APE of 15%. Additionally, all but three LSS examined gave a better prediction of the complete AUC(0–12) in comparison with the trough concentrations C(0) or C(12) (mean 62%). All six LSS based on Bayesian fitting predicted <90% of the 37 complete AUC(0–12) correctly (mean 67%). CONCLUSIONS: The present study indicated that implementation of LSS based on regression analysis could produce satisfactory predictions although careful evaluation is necessary. Springer-Verlag 2007-08-22 2007-11 /pmc/articles/PMC2039832/ /pubmed/17712551 http://dx.doi.org/10.1007/s00228-007-0354-9 Text en © Springer-Verlag 2007
spellingShingle Pharmacokinetics and Disposition
Op den Buijsch, Robert A. M.
van de Plas, Afke
Stolk, Leo M. L.
Christiaans, Maarten H. L.
van Hooff, Johannes P.
Undre, Nas A.
van Dieijen-Visser, Marja P.
Bekers, Otto
Evaluation of limited sampling strategies for tacrolimus
title Evaluation of limited sampling strategies for tacrolimus
title_full Evaluation of limited sampling strategies for tacrolimus
title_fullStr Evaluation of limited sampling strategies for tacrolimus
title_full_unstemmed Evaluation of limited sampling strategies for tacrolimus
title_short Evaluation of limited sampling strategies for tacrolimus
title_sort evaluation of limited sampling strategies for tacrolimus
topic Pharmacokinetics and Disposition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039832/
https://www.ncbi.nlm.nih.gov/pubmed/17712551
http://dx.doi.org/10.1007/s00228-007-0354-9
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