Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics

Aldosterone is synthesised by aldosterone synthase (CYP11B2). CYP11B2 has a highly homologous isoform, steroid 11β-hydroxylase (CYP11B1), which is responsible for the biosynthesis of aldosterone precursors and glucocorticoids. To investigate aldosterone biosynthesis and facilitate the search for sel...

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Detalles Bibliográficos
Autores principales: Roumen, Luc, Sanders, Marijn P. A., Pieterse, Koen, Hilbers, Peter A. J., Plate, Ralf, Custers, Erica, de Gooyer, Marcel, Smits, Jos F. M., Beugels, Ilona, Emmen, Judith, Ottenheijm, Harry C. J., Leysen, Dirk, Hermans, J. J. R.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039848/
https://www.ncbi.nlm.nih.gov/pubmed/17646925
http://dx.doi.org/10.1007/s10822-007-9128-9

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