Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing

BACKGROUND: HTLV-I infected CD4(+ )T-cells lines usually progress towards a CD3(- )or CD3(low )phenotype. In this paper, we studied expression, kinetics, chromatin remodeling of the CD3 gene at different time-points post HTLV-I infection. RESULTS: The onset of this phenomenon coincided with a decrea...

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Detalles Bibliográficos
Autores principales: Akl, Haidar, Badran, Bassam, Dobirta, Gratiela, Manfouo-Foutsop, Germain, Moschitta, Maria, Merimi, Makram, Burny, Arsène, Martiat, Philippe, Willard-Gallo, Karen E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042505/
https://www.ncbi.nlm.nih.gov/pubmed/17822534
http://dx.doi.org/10.1186/1743-422X-4-85

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