The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals

BACKGROUND: The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from...

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Autores principales: Edwards, Carol A, Rens, Willem, Clarke, Oliver, Mungall, Andrew J, Hore, Timothy, Graves, Jennifer A Marshall, Dunham, Ian, Ferguson-Smith, Anne C, Ferguson-Smith, Malcolm A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042987/
https://www.ncbi.nlm.nih.gov/pubmed/17822525
http://dx.doi.org/10.1186/1471-2148-7-157
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author Edwards, Carol A
Rens, Willem
Clarke, Oliver
Mungall, Andrew J
Hore, Timothy
Graves, Jennifer A Marshall
Dunham, Ian
Ferguson-Smith, Anne C
Ferguson-Smith, Malcolm A
author_facet Edwards, Carol A
Rens, Willem
Clarke, Oliver
Mungall, Andrew J
Hore, Timothy
Graves, Jennifer A Marshall
Dunham, Ian
Ferguson-Smith, Anne C
Ferguson-Smith, Malcolm A
author_sort Edwards, Carol A
collection PubMed
description BACKGROUND: The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome. RESULTS: Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial karyotypes. CONCLUSION: These data, along with the similar distribution seen in birds, suggest that imprinted genes were not located on an ancestrally imprinted chromosome or associated with a sex chromosome. Our results suggest imprinting evolution was a stepwise, adaptive process, with each gene/cluster independently becoming imprinted as the need arose.
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spelling pubmed-20429872007-10-27 The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals Edwards, Carol A Rens, Willem Clarke, Oliver Mungall, Andrew J Hore, Timothy Graves, Jennifer A Marshall Dunham, Ian Ferguson-Smith, Anne C Ferguson-Smith, Malcolm A BMC Evol Biol Research Article BACKGROUND: The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome. RESULTS: Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial karyotypes. CONCLUSION: These data, along with the similar distribution seen in birds, suggest that imprinted genes were not located on an ancestrally imprinted chromosome or associated with a sex chromosome. Our results suggest imprinting evolution was a stepwise, adaptive process, with each gene/cluster independently becoming imprinted as the need arose. BioMed Central 2007-09-06 /pmc/articles/PMC2042987/ /pubmed/17822525 http://dx.doi.org/10.1186/1471-2148-7-157 Text en Copyright © 2007 Edwards et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Edwards, Carol A
Rens, Willem
Clarke, Oliver
Mungall, Andrew J
Hore, Timothy
Graves, Jennifer A Marshall
Dunham, Ian
Ferguson-Smith, Anne C
Ferguson-Smith, Malcolm A
The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
title The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
title_full The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
title_fullStr The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
title_full_unstemmed The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
title_short The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
title_sort evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042987/
https://www.ncbi.nlm.nih.gov/pubmed/17822525
http://dx.doi.org/10.1186/1471-2148-7-157
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