Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics

BACKGROUND: The epidermal growth factor receptor (EGFR) plays a critical role in the control of cellular proliferation, differentiation, and survival. Abnormalities in EGF-EGFR signaling, such as mutations that render the EGFR hyperactive or cause overexpression of the wild-type receptor, have been...

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Detalles Bibliográficos
Autores principales: Cragg, Mark S, Kuroda, Junya, Puthalakath, Hamsa, Huang, David C. S, Strasser, Andreas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043013/
https://www.ncbi.nlm.nih.gov/pubmed/17973573
http://dx.doi.org/10.1371/journal.pmed.0040316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043013/
https://www.ncbi.nlm.nih.gov/pubmed/17973573
http://dx.doi.org/10.1371/journal.pmed.0040316

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