Cargando…

Mast cells and eosinophils in invasive breast carcinoma

BACKGROUND: Inflammatory cells in the tumour stroma has gained increasing interest recently. Thus, we aimed to study the frequency and prognostic impact of stromal mast cells and tumour infiltrating eosinophils in invasive breast carcinomas. METHODS: Tissue microarrays containing 234 cases of invasi...

Descripción completa

Detalles Bibliográficos
Autores principales: Amini, Rose-Marie, Aaltonen, Kirsimari, Nevanlinna, Heli, Carvalho, Ricardo, Salonen, Laura, Heikkilä, Päivi, Blomqvist, Carl
Formato: Texto
Lenguaje:English
Publicado: BioMed Central|1 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048965/
https://www.ncbi.nlm.nih.gov/pubmed/17727696
http://dx.doi.org/10.1186/1471-2407-7-165
_version_ 1782137171683049472
author Amini, Rose-Marie
Aaltonen, Kirsimari
Nevanlinna, Heli
Carvalho, Ricardo
Salonen, Laura
Heikkilä, Päivi
Blomqvist, Carl
author_facet Amini, Rose-Marie
Aaltonen, Kirsimari
Nevanlinna, Heli
Carvalho, Ricardo
Salonen, Laura
Heikkilä, Päivi
Blomqvist, Carl
author_sort Amini, Rose-Marie
collection PubMed
description BACKGROUND: Inflammatory cells in the tumour stroma has gained increasing interest recently. Thus, we aimed to study the frequency and prognostic impact of stromal mast cells and tumour infiltrating eosinophils in invasive breast carcinomas. METHODS: Tissue microarrays containing 234 cases of invasive breast cancer were prepared and analysed for the presence of stromal mast cells and eosinophils. Tumour infiltrating eosinophils were counted on hematoxylin-eosin slides. Immunostaining for tryptase was done and the total number of mast cells were counted and correlated to the proliferation marker Ki 67, positivity for estrogen and progesterone receptors, clinical parameters and clinical outcome. RESULTS: Stromal mast cells were found to correlate to low grade tumours and estrogen receptor positivity. There was a total lack of eosinophils in breast cancer tumours. CONCLUSION: A high number of mast cells in the tumours correlated to low-grade tumours and estrogen receptor positivity. Eosinophils are not tumour infiltrating in breast cancers.
format Text
id pubmed-2048965
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher BioMed Central|1
record_format MEDLINE/PubMed
spelling pubmed-20489652007-11-03 Mast cells and eosinophils in invasive breast carcinoma Amini, Rose-Marie Aaltonen, Kirsimari Nevanlinna, Heli Carvalho, Ricardo Salonen, Laura Heikkilä, Päivi Blomqvist, Carl BMC Cancer Research Article BACKGROUND: Inflammatory cells in the tumour stroma has gained increasing interest recently. Thus, we aimed to study the frequency and prognostic impact of stromal mast cells and tumour infiltrating eosinophils in invasive breast carcinomas. METHODS: Tissue microarrays containing 234 cases of invasive breast cancer were prepared and analysed for the presence of stromal mast cells and eosinophils. Tumour infiltrating eosinophils were counted on hematoxylin-eosin slides. Immunostaining for tryptase was done and the total number of mast cells were counted and correlated to the proliferation marker Ki 67, positivity for estrogen and progesterone receptors, clinical parameters and clinical outcome. RESULTS: Stromal mast cells were found to correlate to low grade tumours and estrogen receptor positivity. There was a total lack of eosinophils in breast cancer tumours. CONCLUSION: A high number of mast cells in the tumours correlated to low-grade tumours and estrogen receptor positivity. Eosinophils are not tumour infiltrating in breast cancers. BioMed Central|1 2007-08-29 /pmc/articles/PMC2048965/ /pubmed/17727696 http://dx.doi.org/10.1186/1471-2407-7-165 Text en Copyright © 2007 Amini et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Amini, Rose-Marie
Aaltonen, Kirsimari
Nevanlinna, Heli
Carvalho, Ricardo
Salonen, Laura
Heikkilä, Päivi
Blomqvist, Carl
Mast cells and eosinophils in invasive breast carcinoma
title Mast cells and eosinophils in invasive breast carcinoma
title_full Mast cells and eosinophils in invasive breast carcinoma
title_fullStr Mast cells and eosinophils in invasive breast carcinoma
title_full_unstemmed Mast cells and eosinophils in invasive breast carcinoma
title_short Mast cells and eosinophils in invasive breast carcinoma
title_sort mast cells and eosinophils in invasive breast carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048965/
https://www.ncbi.nlm.nih.gov/pubmed/17727696
http://dx.doi.org/10.1186/1471-2407-7-165
work_keys_str_mv AT aminirosemarie mastcellsandeosinophilsininvasivebreastcarcinoma
AT aaltonenkirsimari mastcellsandeosinophilsininvasivebreastcarcinoma
AT nevanlinnaheli mastcellsandeosinophilsininvasivebreastcarcinoma
AT carvalhoricardo mastcellsandeosinophilsininvasivebreastcarcinoma
AT salonenlaura mastcellsandeosinophilsininvasivebreastcarcinoma
AT heikkilapaivi mastcellsandeosinophilsininvasivebreastcarcinoma
AT blomqvistcarl mastcellsandeosinophilsininvasivebreastcarcinoma