Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.

Neuroblastoma cells express the polysialylated form of the neural cell adhesion molecule (NCAM), which normally becomes restricted to a few neural tissues after embryogenesis. In this study, we investigated serum levels of polysialylated NCAM in 14 children with different grades and stages of neurob...

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Autores principales: Glüer, S., Schelp, C., Madry, N., von Schweinitz, D., Eckhardt, M., Gerardy-Schahn, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062928/
https://www.ncbi.nlm.nih.gov/pubmed/9662259
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author Glüer, S.
Schelp, C.
Madry, N.
von Schweinitz, D.
Eckhardt, M.
Gerardy-Schahn, R.
author_facet Glüer, S.
Schelp, C.
Madry, N.
von Schweinitz, D.
Eckhardt, M.
Gerardy-Schahn, R.
author_sort Glüer, S.
collection PubMed
description Neuroblastoma cells express the polysialylated form of the neural cell adhesion molecule (NCAM), which normally becomes restricted to a few neural tissues after embryogenesis. In this study, we investigated serum levels of polysialylated NCAM in 14 children with different grades and stages of neuroblastoma using an immunoluminescence assay, and compared the results to 269 healthy control subjects. Simultaneously, the polysialylated NCAM content of the tumours was determined by immunohistochemistry. Serum levels were dramatically elevated (more than sixfold) in children with advanced stages and fatal courses of disease, whereas children with differentiated tumour types and limited disease had low or normal levels. Serum concentrations correlated with the polysialylated NCAM content of the tumours, and they decreased during successful therapy. We therefore suggest polysialylated NCAM to be a useful marker monitoring childhood neuroblastoma. IMAGES:
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spelling pubmed-20629282009-09-10 Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma. Glüer, S. Schelp, C. Madry, N. von Schweinitz, D. Eckhardt, M. Gerardy-Schahn, R. Br J Cancer Research Article Neuroblastoma cells express the polysialylated form of the neural cell adhesion molecule (NCAM), which normally becomes restricted to a few neural tissues after embryogenesis. In this study, we investigated serum levels of polysialylated NCAM in 14 children with different grades and stages of neuroblastoma using an immunoluminescence assay, and compared the results to 269 healthy control subjects. Simultaneously, the polysialylated NCAM content of the tumours was determined by immunohistochemistry. Serum levels were dramatically elevated (more than sixfold) in children with advanced stages and fatal courses of disease, whereas children with differentiated tumour types and limited disease had low or normal levels. Serum concentrations correlated with the polysialylated NCAM content of the tumours, and they decreased during successful therapy. We therefore suggest polysialylated NCAM to be a useful marker monitoring childhood neuroblastoma. IMAGES: Nature Publishing Group|1 1998-07 /pmc/articles/PMC2062928/ /pubmed/9662259 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Glüer, S.
Schelp, C.
Madry, N.
von Schweinitz, D.
Eckhardt, M.
Gerardy-Schahn, R.
Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
title Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
title_full Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
title_fullStr Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
title_full_unstemmed Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
title_short Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
title_sort serum polysialylated neural cell adhesion molecule in childhood neuroblastoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062928/
https://www.ncbi.nlm.nih.gov/pubmed/9662259
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