P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.

The expression of the drug resistance (DR) mediators P-glycoprotein (P-gp) and the metallothioneins (MT) was assessed immunohistochemically in biopsy material from patients with high-grade malignant osteosarcoma (OS). No significant difference was found in survival rate between expressors of both P-...

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Autores principales: Shnyder, S. D., Hayes, A. J., Pringle, J., Archer, C. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062957/
https://www.ncbi.nlm.nih.gov/pubmed/9743295
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author Shnyder, S. D.
Hayes, A. J.
Pringle, J.
Archer, C. W.
author_facet Shnyder, S. D.
Hayes, A. J.
Pringle, J.
Archer, C. W.
author_sort Shnyder, S. D.
collection PubMed
description The expression of the drug resistance (DR) mediators P-glycoprotein (P-gp) and the metallothioneins (MT) was assessed immunohistochemically in biopsy material from patients with high-grade malignant osteosarcoma (OS). No significant difference was found in survival rate between expressors of both P-gp and MT and non-expressors. Thus, it was concluded that lack of expression of these two drug resistance-related proteins does not appear to confer any advantage in terms of patient survival in osteosarcoma. IMAGES:
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spelling pubmed-20629572009-09-10 P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. Shnyder, S. D. Hayes, A. J. Pringle, J. Archer, C. W. Br J Cancer Research Article The expression of the drug resistance (DR) mediators P-glycoprotein (P-gp) and the metallothioneins (MT) was assessed immunohistochemically in biopsy material from patients with high-grade malignant osteosarcoma (OS). No significant difference was found in survival rate between expressors of both P-gp and MT and non-expressors. Thus, it was concluded that lack of expression of these two drug resistance-related proteins does not appear to confer any advantage in terms of patient survival in osteosarcoma. IMAGES: Nature Publishing Group|1 1998-09 /pmc/articles/PMC2062957/ /pubmed/9743295 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shnyder, S. D.
Hayes, A. J.
Pringle, J.
Archer, C. W.
P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
title P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
title_full P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
title_fullStr P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
title_full_unstemmed P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
title_short P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
title_sort p-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062957/
https://www.ncbi.nlm.nih.gov/pubmed/9743295
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