Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.

To establish whether loss of heterozygosity (LOH) for chromosome 16q in Wilms' tumours confers an adverse prognosis, DNA from 40 Wilms' tumour/normal pairs were analysed using highly polymorphic microsatellite markers along the length of 16q. Fifteen per cent of tumours showed LOH for 16q....

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Autores principales: Grundy, R. G., Pritchard, J., Scambler, P., Cowell, J. K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063011/
https://www.ncbi.nlm.nih.gov/pubmed/9820177
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author Grundy, R. G.
Pritchard, J.
Scambler, P.
Cowell, J. K.
author_facet Grundy, R. G.
Pritchard, J.
Scambler, P.
Cowell, J. K.
author_sort Grundy, R. G.
collection PubMed
description To establish whether loss of heterozygosity (LOH) for chromosome 16q in Wilms' tumours confers an adverse prognosis, DNA from 40 Wilms' tumour/normal pairs were analysed using highly polymorphic microsatellite markers along the length of 16q. Fifteen per cent of tumours showed LOH for 16q. Although the common region of allele loss spanned the 16q24-qter region, a second distinct region of LOH was identified in 16q21. Five out of six tumours showing LOH were either (1) high stage or (2) low stage with unfavourable histology. In addition, there was a higher mortality rate in patients showing LOH for 16q than those that did not. These data strongly support the suggestion that LOH for 16q is associated with an adverse prognosis. IMAGES:
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spelling pubmed-20630112009-09-10 Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour. Grundy, R. G. Pritchard, J. Scambler, P. Cowell, J. K. Br J Cancer Research Article To establish whether loss of heterozygosity (LOH) for chromosome 16q in Wilms' tumours confers an adverse prognosis, DNA from 40 Wilms' tumour/normal pairs were analysed using highly polymorphic microsatellite markers along the length of 16q. Fifteen per cent of tumours showed LOH for 16q. Although the common region of allele loss spanned the 16q24-qter region, a second distinct region of LOH was identified in 16q21. Five out of six tumours showing LOH were either (1) high stage or (2) low stage with unfavourable histology. In addition, there was a higher mortality rate in patients showing LOH for 16q than those that did not. These data strongly support the suggestion that LOH for 16q is associated with an adverse prognosis. IMAGES: Nature Publishing Group|1 1998-11 /pmc/articles/PMC2063011/ /pubmed/9820177 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Grundy, R. G.
Pritchard, J.
Scambler, P.
Cowell, J. K.
Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.
title Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.
title_full Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.
title_fullStr Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.
title_full_unstemmed Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.
title_short Loss of heterozygosity on chromosome 16 in sporadic Wilms' tumour.
title_sort loss of heterozygosity on chromosome 16 in sporadic wilms' tumour.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063011/
https://www.ncbi.nlm.nih.gov/pubmed/9820177
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AT cowelljk lossofheterozygosityonchromosome16insporadicwilmstumour

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