Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.

Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection...

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Autores principales: Shepherd, F. A., Johnston, M. R., Payne, D., Burkes, R., Deslauriers, J., Cormier, Y., de Bedoya, L. D., Ottaway, J., James, K., Zee, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063048/
https://www.ncbi.nlm.nih.gov/pubmed/9744511
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author Shepherd, F. A.
Johnston, M. R.
Payne, D.
Burkes, R.
Deslauriers, J.
Cormier, Y.
de Bedoya, L. D.
Ottaway, J.
James, K.
Zee, B.
author_facet Shepherd, F. A.
Johnston, M. R.
Payne, D.
Burkes, R.
Deslauriers, J.
Cormier, Y.
de Bedoya, L. D.
Ottaway, J.
James, K.
Zee, B.
author_sort Shepherd, F. A.
collection PubMed
description Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection was possible for 62.5% of patients. Median survival times were 16.2 and 18.7 months for radiotherapy alone and chemotherapy-surgery respectively (P = Ns), with no long-term improvement in survival seen with combined-modality treatment.
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spelling pubmed-20630482009-09-10 Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study. Shepherd, F. A. Johnston, M. R. Payne, D. Burkes, R. Deslauriers, J. Cormier, Y. de Bedoya, L. D. Ottaway, J. James, K. Zee, B. Br J Cancer Research Article Thirty-one patients with stage IIIA (N2) non-small-cell lung cancer were randomized to receive radiotherapy alone or chemotherapy with cisplatin and vinblastine followed by surgery. Response rates to induction chemotherapy and radiotherapy were 50% and 53.3% respectively. Complete surgical resection was possible for 62.5% of patients. Median survival times were 16.2 and 18.7 months for radiotherapy alone and chemotherapy-surgery respectively (P = Ns), with no long-term improvement in survival seen with combined-modality treatment. Nature Publishing Group|1 1998-09 /pmc/articles/PMC2063048/ /pubmed/9744511 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shepherd, F. A.
Johnston, M. R.
Payne, D.
Burkes, R.
Deslauriers, J.
Cormier, Y.
de Bedoya, L. D.
Ottaway, J.
James, K.
Zee, B.
Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
title Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
title_full Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
title_fullStr Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
title_full_unstemmed Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
title_short Randomized study of chemotherapy and surgery versus radiotherapy for stage IIIA non-small-cell lung cancer: a National Cancer Institute of Canada Clinical Trials Group Study.
title_sort randomized study of chemotherapy and surgery versus radiotherapy for stage iiia non-small-cell lung cancer: a national cancer institute of canada clinical trials group study.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063048/
https://www.ncbi.nlm.nih.gov/pubmed/9744511
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