Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.

Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male...

Descripción completa

Detalles Bibliográficos
Autores principales: Taylor, G. M., Dearden, S., Payne, N., Ayres, M., Gokhale, D. A., Birch, J. M., Blair, V., Stevens, R. F., Will, A. M., Eden, O. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063058/
https://www.ncbi.nlm.nih.gov/pubmed/9744491
_version_ 1782137258837540864
author Taylor, G. M.
Dearden, S.
Payne, N.
Ayres, M.
Gokhale, D. A.
Birch, J. M.
Blair, V.
Stevens, R. F.
Will, A. M.
Eden, O. B.
author_facet Taylor, G. M.
Dearden, S.
Payne, N.
Ayres, M.
Gokhale, D. A.
Birch, J. M.
Blair, V.
Stevens, R. F.
Will, A. M.
Eden, O. B.
author_sort Taylor, G. M.
collection PubMed
description Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
format Text
id pubmed-2063058
institution National Center for Biotechnology Information
language English
publishDate 1998
publisher Nature Publishing Group|1
record_format MEDLINE/PubMed
spelling pubmed-20630582009-09-10 Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology. Taylor, G. M. Dearden, S. Payne, N. Ayres, M. Gokhale, D. A. Birch, J. M. Blair, V. Stevens, R. F. Will, A. M. Eden, O. B. Br J Cancer Research Article Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology. Nature Publishing Group|1 1998-09 /pmc/articles/PMC2063058/ /pubmed/9744491 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Taylor, G. M.
Dearden, S.
Payne, N.
Ayres, M.
Gokhale, D. A.
Birch, J. M.
Blair, V.
Stevens, R. F.
Will, A. M.
Eden, O. B.
Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
title Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
title_full Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
title_fullStr Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
title_full_unstemmed Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
title_short Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
title_sort evidence that an hla-dqa1-dqb1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063058/
https://www.ncbi.nlm.nih.gov/pubmed/9744491
work_keys_str_mv AT taylorgm evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT deardens evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT paynen evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT ayresm evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT gokhaleda evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT birchjm evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT blairv evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT stevensrf evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT willam evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology
AT edenob evidencethatanhladqa1dqb1haplotypeinfluencessusceptibilitytochildhoodcommonacutelymphoblasticleukaemiainboysprovidesfurthersupportforaninfectionrelatedaetiology

Ejemplares similares