Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.

Midkine (MK) is a growth factor identified as a product of a retinoic acid-responsive gene. A truncated form of MK mRNA, which lacks a sequence encoding the N-terminally located domain, was recently found in cancer cells. We investigated the expression of the truncated MK mRNA in specimens of 47 sur...

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Autores principales: Aridome, K., Takao, S., Kaname, T., Kadomatsu, K., Natsugoe, S., Kijima, F., Aikou, T., Muramatsu, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063076/
https://www.ncbi.nlm.nih.gov/pubmed/9716029
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author Aridome, K.
Takao, S.
Kaname, T.
Kadomatsu, K.
Natsugoe, S.
Kijima, F.
Aikou, T.
Muramatsu, T.
author_facet Aridome, K.
Takao, S.
Kaname, T.
Kadomatsu, K.
Natsugoe, S.
Kijima, F.
Aikou, T.
Muramatsu, T.
author_sort Aridome, K.
collection PubMed
description Midkine (MK) is a growth factor identified as a product of a retinoic acid-responsive gene. A truncated form of MK mRNA, which lacks a sequence encoding the N-terminally located domain, was recently found in cancer cells. We investigated the expression of the truncated MK mRNA in specimens of 47 surgically removed human gastrointestinal organs using polymerase chain reaction. Truncated MK was not detected in all of the 46 corresponding non-cancerous regions. On the other hand, this short MK mRNA was expressed in the primary tumours in 12 of 16 gastric cancers, 8 of 13 colorectal carcinomas, five of nine hepatocellular carcinomas, two of two oesophageal carcinomas and one ampullary duodenal cancer. In addition, truncated MK was detectable in all of the 14 lymph node metastases but in none of three metastatic sites in the liver, suggesting that truncated MK mRNA could become a good marker of nodal metastases in gastrointestinal tract. IMAGES:
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spelling pubmed-20630762009-09-10 Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas. Aridome, K. Takao, S. Kaname, T. Kadomatsu, K. Natsugoe, S. Kijima, F. Aikou, T. Muramatsu, T. Br J Cancer Research Article Midkine (MK) is a growth factor identified as a product of a retinoic acid-responsive gene. A truncated form of MK mRNA, which lacks a sequence encoding the N-terminally located domain, was recently found in cancer cells. We investigated the expression of the truncated MK mRNA in specimens of 47 surgically removed human gastrointestinal organs using polymerase chain reaction. Truncated MK was not detected in all of the 46 corresponding non-cancerous regions. On the other hand, this short MK mRNA was expressed in the primary tumours in 12 of 16 gastric cancers, 8 of 13 colorectal carcinomas, five of nine hepatocellular carcinomas, two of two oesophageal carcinomas and one ampullary duodenal cancer. In addition, truncated MK was detectable in all of the 14 lymph node metastases but in none of three metastatic sites in the liver, suggesting that truncated MK mRNA could become a good marker of nodal metastases in gastrointestinal tract. IMAGES: Nature Publishing Group|1 1998-08 /pmc/articles/PMC2063076/ /pubmed/9716029 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Aridome, K.
Takao, S.
Kaname, T.
Kadomatsu, K.
Natsugoe, S.
Kijima, F.
Aikou, T.
Muramatsu, T.
Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.
title Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.
title_full Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.
title_fullStr Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.
title_full_unstemmed Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.
title_short Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.
title_sort truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063076/
https://www.ncbi.nlm.nih.gov/pubmed/9716029
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