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Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group.
The purpose of this systematic study was to provide an up to date and reliable quantitative summary of the relative benefits of various types of chemotherapy (non-platinum vs platinum, single-agent vs combination and carboplatin vs cisplatin) in the treatment of advanced ovarian cancer. Also, to inv...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group|1
1998
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063202/ https://www.ncbi.nlm.nih.gov/pubmed/9836481 |
| _version_ | 1782137288552087552 |
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| author | Aabo, K. Adams, M. Adnitt, P. Alberts, D. S. Athanazziou, A. Barley, V. Bell, D. R. Bianchi, U. Bolis, G. Brady, M. F. Brodovsky, H. S. Bruckner, H. Buyse, M. Canetta, R. Chylak, V. Cohen, C. J. Colombo, N. Conte, P. F. Crowther, D. Edmonson, J. H. Gennatas, C. Gilbey, E. Gore, M. Guthrie, D. Yeap, B. Y. |
| author_facet | Aabo, K. Adams, M. Adnitt, P. Alberts, D. S. Athanazziou, A. Barley, V. Bell, D. R. Bianchi, U. Bolis, G. Brady, M. F. Brodovsky, H. S. Bruckner, H. Buyse, M. Canetta, R. Chylak, V. Cohen, C. J. Colombo, N. Conte, P. F. Crowther, D. Edmonson, J. H. Gennatas, C. Gilbey, E. Gore, M. Guthrie, D. Yeap, B. Y. |
| author_sort | Aabo, K. |
| collection | PubMed |
| description | The purpose of this systematic study was to provide an up to date and reliable quantitative summary of the relative benefits of various types of chemotherapy (non-platinum vs platinum, single-agent vs combination and carboplatin vs cisplatin) in the treatment of advanced ovarian cancer. Also, to investigate whether well-defined patient subgroups benefit more or less from cisplatin- or carboplatin-based therapy. Meta-analyses were based on updated individual patient data from all available randomized controlled trials (published and unpublished), including 37 trials, 5667 patients and 4664 deaths. The results suggest that platinum-based chemotherapy is better than non-platinum therapy, show a trend in favour of platinum combinations over single-agent platinum, and suggest that cisplatin and carboplatin are equally effective. There is no good evidence that cisplatin is more or less effective than carboplatin in any particular subgroup of patients. IMAGES: |
| format | Text |
| id | pubmed-2063202 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1998 |
| publisher | Nature Publishing Group|1 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-20632022009-09-10 Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group. Aabo, K. Adams, M. Adnitt, P. Alberts, D. S. Athanazziou, A. Barley, V. Bell, D. R. Bianchi, U. Bolis, G. Brady, M. F. Brodovsky, H. S. Bruckner, H. Buyse, M. Canetta, R. Chylak, V. Cohen, C. J. Colombo, N. Conte, P. F. Crowther, D. Edmonson, J. H. Gennatas, C. Gilbey, E. Gore, M. Guthrie, D. Yeap, B. Y. Br J Cancer Research Article The purpose of this systematic study was to provide an up to date and reliable quantitative summary of the relative benefits of various types of chemotherapy (non-platinum vs platinum, single-agent vs combination and carboplatin vs cisplatin) in the treatment of advanced ovarian cancer. Also, to investigate whether well-defined patient subgroups benefit more or less from cisplatin- or carboplatin-based therapy. Meta-analyses were based on updated individual patient data from all available randomized controlled trials (published and unpublished), including 37 trials, 5667 patients and 4664 deaths. The results suggest that platinum-based chemotherapy is better than non-platinum therapy, show a trend in favour of platinum combinations over single-agent platinum, and suggest that cisplatin and carboplatin are equally effective. There is no good evidence that cisplatin is more or less effective than carboplatin in any particular subgroup of patients. IMAGES: Nature Publishing Group|1 1998-12 /pmc/articles/PMC2063202/ /pubmed/9836481 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Research Article Aabo, K. Adams, M. Adnitt, P. Alberts, D. S. Athanazziou, A. Barley, V. Bell, D. R. Bianchi, U. Bolis, G. Brady, M. F. Brodovsky, H. S. Bruckner, H. Buyse, M. Canetta, R. Chylak, V. Cohen, C. J. Colombo, N. Conte, P. F. Crowther, D. Edmonson, J. H. Gennatas, C. Gilbey, E. Gore, M. Guthrie, D. Yeap, B. Y. Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group. |
| title | Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group. |
| title_full | Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group. |
| title_fullStr | Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group. |
| title_full_unstemmed | Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group. |
| title_short | Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group. |
| title_sort | chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. advanced ovarian cancer trialists' group. |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063202/ https://www.ncbi.nlm.nih.gov/pubmed/9836481 |
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