Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.

The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colore...

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Autores principales: Parsons, S. L., Watson, S. A., Collins, H. M., Griffin, N. R., Clarke, P. A., Steele, R. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063205/
https://www.ncbi.nlm.nih.gov/pubmed/9836483
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author Parsons, S. L.
Watson, S. A.
Collins, H. M.
Griffin, N. R.
Clarke, P. A.
Steele, R. J.
author_facet Parsons, S. L.
Watson, S. A.
Collins, H. M.
Griffin, N. R.
Clarke, P. A.
Steele, R. J.
author_sort Parsons, S. L.
collection PubMed
description The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colorectal adenomas and 13 gastric cancers with corresponding normal mucosa. Overexpression of all the gelatinases occurs in both colorectal and gastric cancer, with activation of MMP-2 appearing to be a feature of the malignant phenotype. Overexpression of MMP-9 occurs in colorectal adenomas. The gelatinases are overexpressed in gastrointestinal neoplasia, suggesting that these enzymes may have an important role in tumour invasion and metastasis. IMAGES:
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spelling pubmed-20632052009-09-10 Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy. Parsons, S. L. Watson, S. A. Collins, H. M. Griffin, N. R. Clarke, P. A. Steele, R. J. Br J Cancer Research Article The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared with normal mucosa. A total of 53 colorectal cancers and corresponding normal mucosa were studied using gelatin zymography as well as 15 colorectal adenomas and 13 gastric cancers with corresponding normal mucosa. Overexpression of all the gelatinases occurs in both colorectal and gastric cancer, with activation of MMP-2 appearing to be a feature of the malignant phenotype. Overexpression of MMP-9 occurs in colorectal adenomas. The gelatinases are overexpressed in gastrointestinal neoplasia, suggesting that these enzymes may have an important role in tumour invasion and metastasis. IMAGES: Nature Publishing Group|1 1998-12 /pmc/articles/PMC2063205/ /pubmed/9836483 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Parsons, S. L.
Watson, S. A.
Collins, H. M.
Griffin, N. R.
Clarke, P. A.
Steele, R. J.
Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.
title Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.
title_full Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.
title_fullStr Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.
title_full_unstemmed Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.
title_short Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy.
title_sort gelatinase (mmp-2 and -9) expression in gastrointestinal malignancy.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063205/
https://www.ncbi.nlm.nih.gov/pubmed/9836483
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