Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.

Human hHb1 belongs to the type II hard keratin family and is physiologically expressed in hair shafts. In the present study, using specific 3' and 5' probes for hHb1, we established that breast carcinomas ectopically express a hHb1 5'-truncated mRNA, and that this transcript is restri...

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Autores principales: Régnier, C. H., Boulay, A., Asch, P. H., Wendling, C., Chenard, M. P., Tomasetto, C., Rio, M. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063233/
https://www.ncbi.nlm.nih.gov/pubmed/9862577
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author Régnier, C. H.
Boulay, A.
Asch, P. H.
Wendling, C.
Chenard, M. P.
Tomasetto, C.
Rio, M. C.
author_facet Régnier, C. H.
Boulay, A.
Asch, P. H.
Wendling, C.
Chenard, M. P.
Tomasetto, C.
Rio, M. C.
author_sort Régnier, C. H.
collection PubMed
description Human hHb1 belongs to the type II hard keratin family and is physiologically expressed in hair shafts. In the present study, using specific 3' and 5' probes for hHb1, we established that breast carcinomas ectopically express a hHb1 5'-truncated mRNA, and that this transcript is restricted to malignant epithelial cells. Furthermore, an in vitro study indicated that it could be translated. We concluded that, in breast carcinomas, expression of truncated hHb1 is related to epithelial cell transformation. Because the hHb1 gene maps to 12q11-q13, a chromosome region known to present several breakpoints in solid tumours, we propose that the hHb1 gene might represent a target for such alterations. IMAGES:
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spelling pubmed-20632332009-09-10 Expression of a truncated form of hHb1 hair keratin in human breast carcinomas. Régnier, C. H. Boulay, A. Asch, P. H. Wendling, C. Chenard, M. P. Tomasetto, C. Rio, M. C. Br J Cancer Research Article Human hHb1 belongs to the type II hard keratin family and is physiologically expressed in hair shafts. In the present study, using specific 3' and 5' probes for hHb1, we established that breast carcinomas ectopically express a hHb1 5'-truncated mRNA, and that this transcript is restricted to malignant epithelial cells. Furthermore, an in vitro study indicated that it could be translated. We concluded that, in breast carcinomas, expression of truncated hHb1 is related to epithelial cell transformation. Because the hHb1 gene maps to 12q11-q13, a chromosome region known to present several breakpoints in solid tumours, we propose that the hHb1 gene might represent a target for such alterations. IMAGES: Nature Publishing Group|1 1998-12 /pmc/articles/PMC2063233/ /pubmed/9862577 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Régnier, C. H.
Boulay, A.
Asch, P. H.
Wendling, C.
Chenard, M. P.
Tomasetto, C.
Rio, M. C.
Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.
title Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.
title_full Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.
title_fullStr Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.
title_full_unstemmed Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.
title_short Expression of a truncated form of hHb1 hair keratin in human breast carcinomas.
title_sort expression of a truncated form of hhb1 hair keratin in human breast carcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063233/
https://www.ncbi.nlm.nih.gov/pubmed/9862577
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