Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.

Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for...

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Autores principales: Iida, A., Isobe, R., Yoshimoto, M., Kasumi, F., Nakamura, Y., Emi, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063259/
https://www.ncbi.nlm.nih.gov/pubmed/9010036
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author Iida, A.
Isobe, R.
Yoshimoto, M.
Kasumi, F.
Nakamura, Y.
Emi, M.
author_facet Iida, A.
Isobe, R.
Yoshimoto, M.
Kasumi, F.
Nakamura, Y.
Emi, M.
author_sort Iida, A.
collection PubMed
description Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515 at 16q22; the second consisted of a 9.5-cM interval flanked by markers D16S498 and D16S303 at q24.3. Allelic loss on 16q was observed frequently in small tumours, tumours without lymph node metastasis and tumours of the non-invasive histological type as well as in tumours of more advanced phenotype, suggesting that inactivation of one of at least two tumour-suppressor genes on 16q plays a role in early stage breast carcinogenesis. IMAGES:
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spelling pubmed-20632592009-09-10 Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22. Iida, A. Isobe, R. Yoshimoto, M. Kasumi, F. Nakamura, Y. Emi, M. Br J Cancer Research Article Allelic losses on chromosome 16q in tumour cells are frequent in a variety of malignancies, suggesting the presence of one or more tumour-suppressor genes in the region. Among 210 sporadic breast cancers we examined using 15 microsatellite markers on the long arm of chromosome 16, heterozygosity for at least one locus was lost in 141 (67%). Detailed deletion mapping revealed two distinct commonly deleted regions. One region was defined as a 3-cM interval flanked by markers D16S512 and D16S515 at 16q22; the second consisted of a 9.5-cM interval flanked by markers D16S498 and D16S303 at q24.3. Allelic loss on 16q was observed frequently in small tumours, tumours without lymph node metastasis and tumours of the non-invasive histological type as well as in tumours of more advanced phenotype, suggesting that inactivation of one of at least two tumour-suppressor genes on 16q plays a role in early stage breast carcinogenesis. IMAGES: Nature Publishing Group|1 1997 /pmc/articles/PMC2063259/ /pubmed/9010036 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Iida, A.
Isobe, R.
Yoshimoto, M.
Kasumi, F.
Nakamura, Y.
Emi, M.
Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.
title Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.
title_full Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.
title_fullStr Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.
title_full_unstemmed Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.
title_short Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.
title_sort localization of a breast cancer tumour-suppressor gene to a 3-cm interval within chromosomal region 16q22.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063259/
https://www.ncbi.nlm.nih.gov/pubmed/9010036
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