Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.

Immunohistochemical staining of bcl-2 and p53 proteins was compared with thymidine labelling index (TLI) and cell loss factor (O) in lung cancer. Neither bcl-2 nor p53 overexpression was associated with high cell loss but strong bcl-2 staining was associated with higher TLI. Concomitant strong p53 a...

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Autores principales: Kennedy, M. M., Lamb, D., King, G., Kerr, K. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063319/
https://www.ncbi.nlm.nih.gov/pubmed/9052408
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author Kennedy, M. M.
Lamb, D.
King, G.
Kerr, K. M.
author_facet Kennedy, M. M.
Lamb, D.
King, G.
Kerr, K. M.
author_sort Kennedy, M. M.
collection PubMed
description Immunohistochemical staining of bcl-2 and p53 proteins was compared with thymidine labelling index (TLI) and cell loss factor (O) in lung cancer. Neither bcl-2 nor p53 overexpression was associated with high cell loss but strong bcl-2 staining was associated with higher TLI. Concomitant strong p53 and bcl-2 expression, not the usual inverse relationship, plus high cell-loss factor was present in three neuroendocrine carcinomas. Other factors presumably have a role in controlling cell death in these tumours.
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spelling pubmed-20633192009-09-10 Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms. Kennedy, M. M. Lamb, D. King, G. Kerr, K. M. Br J Cancer Research Article Immunohistochemical staining of bcl-2 and p53 proteins was compared with thymidine labelling index (TLI) and cell loss factor (O) in lung cancer. Neither bcl-2 nor p53 overexpression was associated with high cell loss but strong bcl-2 staining was associated with higher TLI. Concomitant strong p53 and bcl-2 expression, not the usual inverse relationship, plus high cell-loss factor was present in three neuroendocrine carcinomas. Other factors presumably have a role in controlling cell death in these tumours. Nature Publishing Group|1 1997 /pmc/articles/PMC2063319/ /pubmed/9052408 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kennedy, M. M.
Lamb, D.
King, G.
Kerr, K. M.
Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
title Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
title_full Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
title_fullStr Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
title_full_unstemmed Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
title_short Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
title_sort cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063319/
https://www.ncbi.nlm.nih.gov/pubmed/9052408
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