Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.

Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG...

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Autores principales: Lou, M. A., Tseng, S. L., Chang, S. F., Yue, C. T., Chang, B. L., Chou, C. H., Yang, S. L., Teh, B. H., Wu, C. W., Shen, C. Y.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063343/
https://www.ncbi.nlm.nih.gov/pubmed/9043035
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author Lou, M. A.
Tseng, S. L.
Chang, S. F.
Yue, C. T.
Chang, B. L.
Chou, C. H.
Yang, S. L.
Teh, B. H.
Wu, C. W.
Shen, C. Y.
author_facet Lou, M. A.
Tseng, S. L.
Chang, S. F.
Yue, C. T.
Chang, B. L.
Chou, C. H.
Yang, S. L.
Teh, B. H.
Wu, C. W.
Shen, C. Y.
author_sort Lou, M. A.
collection PubMed
description Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area. IMAGES:
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spelling pubmed-20633432009-09-10 Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area. Lou, M. A. Tseng, S. L. Chang, S. F. Yue, C. T. Chang, B. L. Chou, C. H. Yang, S. L. Teh, B. H. Wu, C. W. Shen, C. Y. Br J Cancer Research Article Among 114 breast cancers in Taiwan, the prevalence of p53 mutation (22.8%) and p53 accumulation (38.3%) was similar to that in high-incidence areas. However, novel patterns of p53 abnormalities, including unique sites or types of mutation (i.e. an excessive proportion of G:C to A:T transition at CpG site), and accumulation of wild-type p53 either within nuclear or cytoplasmic compartments were noted. These may have relevance to breast cancer in Taiwan, a low-incidence area. IMAGES: Nature Publishing Group|1 1997 /pmc/articles/PMC2063343/ /pubmed/9043035 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lou, M. A.
Tseng, S. L.
Chang, S. F.
Yue, C. T.
Chang, B. L.
Chou, C. H.
Yang, S. L.
Teh, B. H.
Wu, C. W.
Shen, C. Y.
Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
title Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
title_full Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
title_fullStr Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
title_full_unstemmed Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
title_short Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area.
title_sort novel patterns of p53 abnormality in breast cancer from taiwan: experience from a low-incidence area.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063343/
https://www.ncbi.nlm.nih.gov/pubmed/9043035
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