Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.

We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid compo...

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Autores principales: Noguchi, M., Minami, M., Yagasaki, R., Kinoshita, K., Earashi, M., Kitagawa, H., Taniya, T., Miyazaki, I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063366/
https://www.ncbi.nlm.nih.gov/pubmed/9020478
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author Noguchi, M.
Minami, M.
Yagasaki, R.
Kinoshita, K.
Earashi, M.
Kitagawa, H.
Taniya, T.
Miyazaki, I.
author_facet Noguchi, M.
Minami, M.
Yagasaki, R.
Kinoshita, K.
Earashi, M.
Kitagawa, H.
Taniya, T.
Miyazaki, I.
author_sort Noguchi, M.
collection PubMed
description We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer.
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spelling pubmed-20633662009-09-10 Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. Noguchi, M. Minami, M. Yagasaki, R. Kinoshita, K. Earashi, M. Kitagawa, H. Taniya, T. Miyazaki, I. Br J Cancer Research Article We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer. Nature Publishing Group|1 1997 /pmc/articles/PMC2063366/ /pubmed/9020478 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Noguchi, M.
Minami, M.
Yagasaki, R.
Kinoshita, K.
Earashi, M.
Kitagawa, H.
Taniya, T.
Miyazaki, I.
Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
title Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
title_full Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
title_fullStr Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
title_full_unstemmed Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
title_short Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA.
title_sort chemoprevention of dmba-induced mammary carcinogenesis in rats by low-dose epa and dha.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063366/
https://www.ncbi.nlm.nih.gov/pubmed/9020478
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