Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.

In the last year, a number of studies have reported the expression of bcl-2 in colorectal adenocarcinomas. However, the influence of bcl-2 expression on response to chemotherapy and outcome in patients with advanced colorectal adenocarcinoma has not been reported. We analysed bcl-2 expression in 231...

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Autores principales: Schneider, H. J., Sampson, S. A., Cunningham, D., Norman, A. R., Andreyev, H. J., Tilsed, J. V., Clarke, P. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063374/
https://www.ncbi.nlm.nih.gov/pubmed/9020491
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author Schneider, H. J.
Sampson, S. A.
Cunningham, D.
Norman, A. R.
Andreyev, H. J.
Tilsed, J. V.
Clarke, P. A.
author_facet Schneider, H. J.
Sampson, S. A.
Cunningham, D.
Norman, A. R.
Andreyev, H. J.
Tilsed, J. V.
Clarke, P. A.
author_sort Schneider, H. J.
collection PubMed
description In the last year, a number of studies have reported the expression of bcl-2 in colorectal adenocarcinomas. However, the influence of bcl-2 expression on response to chemotherapy and outcome in patients with advanced colorectal adenocarcinoma has not been reported. We analysed bcl-2 expression in 231 colorectal tumours from patients that were treated by surgery alone or with 5-fluorouracil-based chemotherapy. Of 231 tumours, 149 (64.5%) overexpressed bcl-2. Bcl-2 expression was associated with low plasma CEA levels (P=0.013) and inversely associated with poor differentiation (P=0.049). However, bcl-2 expression did not significantly influence failure-free or overall survival in surgically treated patients. In the group of patients receiving 5-fluorouracil-based chemotherapy bcl-2 expression did not influence response to chemotherapy; nor did it effect failure-free or overall survival. IMAGES:
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spelling pubmed-20633742009-09-10 Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas. Schneider, H. J. Sampson, S. A. Cunningham, D. Norman, A. R. Andreyev, H. J. Tilsed, J. V. Clarke, P. A. Br J Cancer Research Article In the last year, a number of studies have reported the expression of bcl-2 in colorectal adenocarcinomas. However, the influence of bcl-2 expression on response to chemotherapy and outcome in patients with advanced colorectal adenocarcinoma has not been reported. We analysed bcl-2 expression in 231 colorectal tumours from patients that were treated by surgery alone or with 5-fluorouracil-based chemotherapy. Of 231 tumours, 149 (64.5%) overexpressed bcl-2. Bcl-2 expression was associated with low plasma CEA levels (P=0.013) and inversely associated with poor differentiation (P=0.049). However, bcl-2 expression did not significantly influence failure-free or overall survival in surgically treated patients. In the group of patients receiving 5-fluorouracil-based chemotherapy bcl-2 expression did not influence response to chemotherapy; nor did it effect failure-free or overall survival. IMAGES: Nature Publishing Group|1 1997 /pmc/articles/PMC2063374/ /pubmed/9020491 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Schneider, H. J.
Sampson, S. A.
Cunningham, D.
Norman, A. R.
Andreyev, H. J.
Tilsed, J. V.
Clarke, P. A.
Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
title Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
title_full Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
title_fullStr Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
title_full_unstemmed Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
title_short Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
title_sort bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063374/
https://www.ncbi.nlm.nih.gov/pubmed/9020491
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