Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata.

The present paper describes two immunoconjugates consisting of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb), named Mint5, covalently linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine (Pyra) from Saponaria ocymoides and Vaccaria...

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Autores principales: Di Massimo, A. M., Di Loreto, M., Pacilli, A., Raucci, G., D'Alatri, L., Mele, A., Bolognesi, A., Polito, L., Stirpe, F., De Santis, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063398/
https://www.ncbi.nlm.nih.gov/pubmed/9062402
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author Di Massimo, A. M.
Di Loreto, M.
Pacilli, A.
Raucci, G.
D'Alatri, L.
Mele, A.
Bolognesi, A.
Polito, L.
Stirpe, F.
De Santis, R.
author_facet Di Massimo, A. M.
Di Loreto, M.
Pacilli, A.
Raucci, G.
D'Alatri, L.
Mele, A.
Bolognesi, A.
Polito, L.
Stirpe, F.
De Santis, R.
author_sort Di Massimo, A. M.
collection PubMed
description The present paper describes two immunoconjugates consisting of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb), named Mint5, covalently linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine (Pyra) from Saponaria ocymoides and Vaccaria pyramidata respectively. Both antibody and toxins are shown to retain their respective biological properties upon chemical conjugation. The immunoconjugates exert specific inhibition of EGFR expressing target cell proliferation and protein synthesis in in vitro assays and also inhibit the growth of grafted human tumour cells in nude mice. IMAGES:
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spelling pubmed-20633982009-09-10 Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata. Di Massimo, A. M. Di Loreto, M. Pacilli, A. Raucci, G. D'Alatri, L. Mele, A. Bolognesi, A. Polito, L. Stirpe, F. De Santis, R. Br J Cancer Research Article The present paper describes two immunoconjugates consisting of an anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb), named Mint5, covalently linked to the type 1 ribosome-inactivating proteins (RIPs) ocymoidine (Ocy) and pyramidatine (Pyra) from Saponaria ocymoides and Vaccaria pyramidata respectively. Both antibody and toxins are shown to retain their respective biological properties upon chemical conjugation. The immunoconjugates exert specific inhibition of EGFR expressing target cell proliferation and protein synthesis in in vitro assays and also inhibit the growth of grafted human tumour cells in nude mice. IMAGES: Nature Publishing Group|1 1997 /pmc/articles/PMC2063398/ /pubmed/9062402 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Di Massimo, A. M.
Di Loreto, M.
Pacilli, A.
Raucci, G.
D'Alatri, L.
Mele, A.
Bolognesi, A.
Polito, L.
Stirpe, F.
De Santis, R.
Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata.
title Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata.
title_full Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata.
title_fullStr Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata.
title_full_unstemmed Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata.
title_short Immunoconjugates made of an anti-EGF receptor monoclonal antibody and type 1 ribosome-inactivating proteins from Saponaria ocymoides or Vaccaria pyramidata.
title_sort immunoconjugates made of an anti-egf receptor monoclonal antibody and type 1 ribosome-inactivating proteins from saponaria ocymoides or vaccaria pyramidata.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063398/
https://www.ncbi.nlm.nih.gov/pubmed/9062402
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