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Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK
Regulated phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α) by the endoplasmic reticulum (ER) stress-activated protein kinase PERK modulates protein synthesis and couples the production of ER client proteins with the organelle's capacity to fold and process...
Autores principales: | Marciniak, Stefan J., Garcia-Bonilla, Lidia, Hu, Junjie, Harding, Heather P., Ron, David |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063550/ https://www.ncbi.nlm.nih.gov/pubmed/16418533 http://dx.doi.org/10.1083/jcb.200508099 |
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