Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

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AIMS/HYPOTHESIS: Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin secretion. The transcription factor TCF7L2 is an essential factor for glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells. We studied whether a defe...

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Detalles Bibliográficos
Autores principales: Schäfer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, J. J., Dekker, J. M., t’Hart, L. M., Nijpels, G., van Haeften, T. W., Häring, H. U., Fritsche, A.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063563/
https://www.ncbi.nlm.nih.gov/pubmed/17661009
http://dx.doi.org/10.1007/s00125-007-0753-6
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