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Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility
Rho GTPases participate in various cellular processes, including normal and tumor cell migration. It has been reported that RhoA is targeted for degradation at the leading edge of migrating cells by the E3 ubiquitin ligase Smurf1, and that this is required for the formation of protrusions. We report...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063621/ https://www.ncbi.nlm.nih.gov/pubmed/17190792 http://dx.doi.org/10.1083/jcb.200605135 |