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Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Mutations within the WNK1 (with-no-K[Lys] kinase-1) gene cause Gordon's hypertension syndrome. Little is known about how WNK1 is regulated. We demonstrate that WNK1 is rapidly activated and phosphorylated at multiple residues after exposure of cells to hyperosmotic conditions and that activatio...

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Detalles Bibliográficos
Autores principales:	Zagórska, Anna, Pozo-Guisado, Eulalia, Boudeau, Jérôme, Vitari, Alberto C., Rafiqi, Fatema H., Thastrup, Jacob, Deak, Maria, Campbell, David G., Morrice, Nick A., Prescott, Alan R., Alessi, Dario R.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063630/ https://www.ncbi.nlm.nih.gov/pubmed/17190791 http://dx.doi.org/10.1083/jcb.200605093

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