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Huntingtin–HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease

The molecular mechanisms underlying the targeting of Huntingtin (Htt) to endosomes and its multifaceted role in endocytosis are poorly understood. In this study, we have identified Htt-associated protein 40 (HAP40) as a novel effector of the small guanosine triphosphatase Rab5, a key regulator of en...

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Detalles Bibliográficos
Autores principales: Pal, Arun, Severin, Fedor, Lommer, Barbara, Shevchenko, Anna, Zerial, Marino
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063679/
https://www.ncbi.nlm.nih.gov/pubmed/16476778
http://dx.doi.org/10.1083/jcb.200509091