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Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins

The Ras superfamily is comprised of at least four large families of regulatory guanosine triphosphate–binding proteins, including the Arfs. The Arf family includes three different groups of proteins: the Arfs, Arf-like (Arls), and SARs. Several Arf family members have been very highly conserved thro...

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Detalles Bibliográficos
Autores principales: Kahn, Richard A., Cherfils, Jacqueline, Elias, Marek, Lovering, Ruth C., Munro, Sean, Schurmann, Annette
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063696/
https://www.ncbi.nlm.nih.gov/pubmed/16505163
http://dx.doi.org/10.1083/jcb.200512057
Descripción
Sumario:The Ras superfamily is comprised of at least four large families of regulatory guanosine triphosphate–binding proteins, including the Arfs. The Arf family includes three different groups of proteins: the Arfs, Arf-like (Arls), and SARs. Several Arf family members have been very highly conserved throughout eukaryotic evolution and have orthologues in evolutionally diverse species. The different means by which Arf family members have been identified have resulted in an inconsistent and confusing array of names. This confusion is further compounded by differences in nomenclature between different species. We propose a more consistent nomenclature for the human members of the Arf family that may also serve as a guide for nomenclature in other species.