A +TIP for a smooth trip

Is there a cellular mechanism for preventing a depolymerizing microtubule track from “slipping out from under” its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end–tracking pro...

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Detalles Bibliográficos
Autor principal: Xiang, Xin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063697/
https://www.ncbi.nlm.nih.gov/pubmed/16492810
http://dx.doi.org/10.1083/jcb.200511081
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author Xiang, Xin
author_facet Xiang, Xin
author_sort Xiang, Xin
collection PubMed
description Is there a cellular mechanism for preventing a depolymerizing microtubule track from “slipping out from under” its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end–tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation.
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spelling pubmed-20636972007-11-29 A +TIP for a smooth trip Xiang, Xin J Cell Biol Reviews Is there a cellular mechanism for preventing a depolymerizing microtubule track from “slipping out from under” its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end–tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation. The Rockefeller University Press 2006-02-27 /pmc/articles/PMC2063697/ /pubmed/16492810 http://dx.doi.org/10.1083/jcb.200511081 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Xiang, Xin
A +TIP for a smooth trip
title A +TIP for a smooth trip
title_full A +TIP for a smooth trip
title_fullStr A +TIP for a smooth trip
title_full_unstemmed A +TIP for a smooth trip
title_short A +TIP for a smooth trip
title_sort +tip for a smooth trip
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063697/
https://www.ncbi.nlm.nih.gov/pubmed/16492810
http://dx.doi.org/10.1083/jcb.200511081
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