Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development

A series of in vitro tissue culture studies indicated that the p53 tumor suppressor promotes cellular differentiation, which could explain its role in preventing cancer. Quite surprisingly, however, two new in vivo studies (Lengner et al., 2006; Wang et al., 2006) provide genetic evidence that p53 b...

Descripción completa

Detalles Bibliográficos
Autores principales: Zambetti, Gerard P., Horwitz, Edwin M., Schipani, Ernestina
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063722/
https://www.ncbi.nlm.nih.gov/pubmed/16533941
http://dx.doi.org/10.1083/jcb.200601114
_version_ 1782137376771932160
author Zambetti, Gerard P.
Horwitz, Edwin M.
Schipani, Ernestina
author_facet Zambetti, Gerard P.
Horwitz, Edwin M.
Schipani, Ernestina
author_sort Zambetti, Gerard P.
collection PubMed
description A series of in vitro tissue culture studies indicated that the p53 tumor suppressor promotes cellular differentiation, which could explain its role in preventing cancer. Quite surprisingly, however, two new in vivo studies (Lengner et al., 2006; Wang et al., 2006) provide genetic evidence that p53 blocks osteoblast differentiation and bone development. These interesting results and their biological and clinical implications are the focus of this comment.
format Text
id pubmed-2063722
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-20637222007-11-29 Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development Zambetti, Gerard P. Horwitz, Edwin M. Schipani, Ernestina J Cell Biol Reviews A series of in vitro tissue culture studies indicated that the p53 tumor suppressor promotes cellular differentiation, which could explain its role in preventing cancer. Quite surprisingly, however, two new in vivo studies (Lengner et al., 2006; Wang et al., 2006) provide genetic evidence that p53 blocks osteoblast differentiation and bone development. These interesting results and their biological and clinical implications are the focus of this comment. The Rockefeller University Press 2006-03-13 /pmc/articles/PMC2063722/ /pubmed/16533941 http://dx.doi.org/10.1083/jcb.200601114 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Zambetti, Gerard P.
Horwitz, Edwin M.
Schipani, Ernestina
Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
title Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
title_full Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
title_fullStr Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
title_full_unstemmed Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
title_short Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
title_sort skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063722/
https://www.ncbi.nlm.nih.gov/pubmed/16533941
http://dx.doi.org/10.1083/jcb.200601114
work_keys_str_mv AT zambettigerardp skeletonsinthep53tumorsuppressorclosetgeneticevidencethatp53blocksbonedifferentiationanddevelopment
AT horwitzedwinm skeletonsinthep53tumorsuppressorclosetgeneticevidencethatp53blocksbonedifferentiationanddevelopment
AT schipaniernestina skeletonsinthep53tumorsuppressorclosetgeneticevidencethatp53blocksbonedifferentiationanddevelopment

Ejemplares similares