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CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion

Toll-like receptors (TLRs) recognize molecular patterns preferentially expressed by pathogens. In endosomes, TLR9 is activated by unmethylated bacterial DNA, resulting in proinflammatory cytokine secretion via the adaptor protein MyD88. We demonstrate that CpG oligonucleotides activate a TLR9-indepe...

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Detalles Bibliográficos
Autores principales:	Sanjuan, Miguel A., Rao, Navin, Lai, Kuei-Tai A., Gu, Yin, Sun, Siquan, Fuchs, Anja, Fung-Leung, Wai-Ping, Colonna, Marco, Karlsson, Lars
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063763/ https://www.ncbi.nlm.nih.gov/pubmed/16567503 http://dx.doi.org/10.1083/jcb.200508058

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