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Caspases leave the beaten track: caspase-mediated activation of NF-κB

The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfil...

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Detalles Bibliográficos
Autores principales: Lamkanfi, Mohamed, Declercq, Wim, Vanden Berghe, Tom, Vandenabeele, Peter
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063807/
https://www.ncbi.nlm.nih.gov/pubmed/16618810
http://dx.doi.org/10.1083/jcb.200509092
Descripción
Sumario:The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfils a central role in innate and adaptive immunity, in cellular stress responses and in the induction of anti-apoptotic factors. Two different mechanisms by which caspases activate the NF-κB pathway are discussed.