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Caspases leave the beaten track: caspase-mediated activation of NF-κB
The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfil...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063807/ https://www.ncbi.nlm.nih.gov/pubmed/16618810 http://dx.doi.org/10.1083/jcb.200509092 |
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author | Lamkanfi, Mohamed Declercq, Wim Vanden Berghe, Tom Vandenabeele, Peter |
author_facet | Lamkanfi, Mohamed Declercq, Wim Vanden Berghe, Tom Vandenabeele, Peter |
author_sort | Lamkanfi, Mohamed |
collection | PubMed |
description | The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfils a central role in innate and adaptive immunity, in cellular stress responses and in the induction of anti-apoptotic factors. Two different mechanisms by which caspases activate the NF-κB pathway are discussed. |
format | Text |
id | pubmed-2063807 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-20638072007-11-29 Caspases leave the beaten track: caspase-mediated activation of NF-κB Lamkanfi, Mohamed Declercq, Wim Vanden Berghe, Tom Vandenabeele, Peter J Cell Biol Reviews The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfils a central role in innate and adaptive immunity, in cellular stress responses and in the induction of anti-apoptotic factors. Two different mechanisms by which caspases activate the NF-κB pathway are discussed. The Rockefeller University Press 2006-04-24 /pmc/articles/PMC2063807/ /pubmed/16618810 http://dx.doi.org/10.1083/jcb.200509092 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Lamkanfi, Mohamed Declercq, Wim Vanden Berghe, Tom Vandenabeele, Peter Caspases leave the beaten track: caspase-mediated activation of NF-κB |
title | Caspases leave the beaten track: caspase-mediated activation of NF-κB |
title_full | Caspases leave the beaten track: caspase-mediated activation of NF-κB |
title_fullStr | Caspases leave the beaten track: caspase-mediated activation of NF-κB |
title_full_unstemmed | Caspases leave the beaten track: caspase-mediated activation of NF-κB |
title_short | Caspases leave the beaten track: caspase-mediated activation of NF-κB |
title_sort | caspases leave the beaten track: caspase-mediated activation of nf-κb |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063807/ https://www.ncbi.nlm.nih.gov/pubmed/16618810 http://dx.doi.org/10.1083/jcb.200509092 |
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