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Caspases leave the beaten track: caspase-mediated activation of NF-κB

The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfil...

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Detalles Bibliográficos
Autores principales: Lamkanfi, Mohamed, Declercq, Wim, Vanden Berghe, Tom, Vandenabeele, Peter
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063807/
https://www.ncbi.nlm.nih.gov/pubmed/16618810
http://dx.doi.org/10.1083/jcb.200509092
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author Lamkanfi, Mohamed
Declercq, Wim
Vanden Berghe, Tom
Vandenabeele, Peter
author_facet Lamkanfi, Mohamed
Declercq, Wim
Vanden Berghe, Tom
Vandenabeele, Peter
author_sort Lamkanfi, Mohamed
collection PubMed
description The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfils a central role in innate and adaptive immunity, in cellular stress responses and in the induction of anti-apoptotic factors. Two different mechanisms by which caspases activate the NF-κB pathway are discussed.
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spelling pubmed-20638072007-11-29 Caspases leave the beaten track: caspase-mediated activation of NF-κB Lamkanfi, Mohamed Declercq, Wim Vanden Berghe, Tom Vandenabeele, Peter J Cell Biol Reviews The proteolytic activity of the cysteinyl aspartate–specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor κB (NF-κB), a transcription factor that fulfils a central role in innate and adaptive immunity, in cellular stress responses and in the induction of anti-apoptotic factors. Two different mechanisms by which caspases activate the NF-κB pathway are discussed. The Rockefeller University Press 2006-04-24 /pmc/articles/PMC2063807/ /pubmed/16618810 http://dx.doi.org/10.1083/jcb.200509092 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Lamkanfi, Mohamed
Declercq, Wim
Vanden Berghe, Tom
Vandenabeele, Peter
Caspases leave the beaten track: caspase-mediated activation of NF-κB
title Caspases leave the beaten track: caspase-mediated activation of NF-κB
title_full Caspases leave the beaten track: caspase-mediated activation of NF-κB
title_fullStr Caspases leave the beaten track: caspase-mediated activation of NF-κB
title_full_unstemmed Caspases leave the beaten track: caspase-mediated activation of NF-κB
title_short Caspases leave the beaten track: caspase-mediated activation of NF-κB
title_sort caspases leave the beaten track: caspase-mediated activation of nf-κb
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063807/
https://www.ncbi.nlm.nih.gov/pubmed/16618810
http://dx.doi.org/10.1083/jcb.200509092
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