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Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells

In neuroendocrine PC12 cells, immature secretory granules (ISGs) mature through homotypic fusion and membrane remodeling. We present evidence that the ISG-localized synaptotagmin IV (Syt IV) is involved in ISG maturation. Using an in vitro homotypic fusion assay, we show that the cytoplasmic domain...

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Detalles Bibliográficos
Autores principales:	Ahras, Malika, Otto, Grant P., Tooze, Sharon A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063815/ https://www.ncbi.nlm.nih.gov/pubmed/16618809 http://dx.doi.org/10.1083/jcb.200506163

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