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IκBɛ provides negative feedback to control NF-κB oscillations, signaling dynamics, and inflammatory gene expression
NF-κB signaling is known to be critically regulated by the NF-κB–inducible inhibitor protein IκBα. The resulting negative feedback has been shown to produce a propensity for oscillations in NF-κB activity. We report integrated experimental and computational studies that demonstrate that another IκB...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063883/ https://www.ncbi.nlm.nih.gov/pubmed/16735576 http://dx.doi.org/10.1083/jcb.200510155 |