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Myosin motor Myo1c and its receptor NEMO/IKK-γ promote TNF-α–induced serine(307) phosphorylation of IRS-1
Tumor necrosis factor-α (TNF-α) signaling through the IκB kinase (IKK) complex attenuates insulin action via the phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser(307). However, the precise molecular mechanism by which the IKK complex phosphorylates IRS-1 is unknown. In this study, we r...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063884/ https://www.ncbi.nlm.nih.gov/pubmed/16754954 http://dx.doi.org/10.1083/jcb.200601065 |