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The chromosomal passenger complex: guiding Aurora-B through mitosis
During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase....
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063908/ https://www.ncbi.nlm.nih.gov/pubmed/16769825 http://dx.doi.org/10.1083/jcb.200604032 |
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author | Vader, Gerben Medema, René H. Lens, Susanne M.A. |
author_facet | Vader, Gerben Medema, René H. Lens, Susanne M.A. |
author_sort | Vader, Gerben |
collection | PubMed |
description | During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase. We discuss the molecular mechanisms by which the CPC members direct the dynamic localization of the complex throughout cell division. Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex. |
format | Text |
id | pubmed-2063908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-20639082007-11-29 The chromosomal passenger complex: guiding Aurora-B through mitosis Vader, Gerben Medema, René H. Lens, Susanne M.A. J Cell Biol Reviews During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase. We discuss the molecular mechanisms by which the CPC members direct the dynamic localization of the complex throughout cell division. Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex. The Rockefeller University Press 2006-06-19 /pmc/articles/PMC2063908/ /pubmed/16769825 http://dx.doi.org/10.1083/jcb.200604032 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Vader, Gerben Medema, René H. Lens, Susanne M.A. The chromosomal passenger complex: guiding Aurora-B through mitosis |
title | The chromosomal passenger complex: guiding Aurora-B through mitosis |
title_full | The chromosomal passenger complex: guiding Aurora-B through mitosis |
title_fullStr | The chromosomal passenger complex: guiding Aurora-B through mitosis |
title_full_unstemmed | The chromosomal passenger complex: guiding Aurora-B through mitosis |
title_short | The chromosomal passenger complex: guiding Aurora-B through mitosis |
title_sort | chromosomal passenger complex: guiding aurora-b through mitosis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063908/ https://www.ncbi.nlm.nih.gov/pubmed/16769825 http://dx.doi.org/10.1083/jcb.200604032 |
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