Aberrant monomethylation of histone H4 lysine 20 activates the DNA damage checkpoint in Drosophila melanogaster

PR-Set7 is a histone methyltransferase that specifically monomethylates histone H4 lysine 20 (K20) and is essential for cell proliferation. Our results show that in PR-Set7 mutants, the DNA damage checkpoint is activated. This phenotype is manifested by reduction in both the mitotic and the S phase...

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Detalles Bibliográficos
Autores principales: Sakaguchi, Ayako, Steward, Ruth
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063935/
https://www.ncbi.nlm.nih.gov/pubmed/17227890
http://dx.doi.org/10.1083/jcb.200607178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063935/
https://www.ncbi.nlm.nih.gov/pubmed/17227890
http://dx.doi.org/10.1083/jcb.200607178

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