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Fibrillin-1 regulates the bioavailability of TGFβ1

We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) β1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFβ signaling is a major contributor to the pathology of Marfan syndrome (MFS...

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Detalles Bibliográficos
Autores principales:	Chaudhry, Shazia S., Cain, Stuart A., Morgan, Amanda, Dallas, Sarah L., Shuttleworth, C. Adrian, Kielty, Cay M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063961/ https://www.ncbi.nlm.nih.gov/pubmed/17242066 http://dx.doi.org/10.1083/jcb.200608167

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